Review Principles of protein-protein interactions
نویسندگان
چکیده
This review examines protein complexes in the Brookhaven Protein Databank to gain a better understanding of the principles governing the interactions involved in protein-protein recognition. The factors that influence the formation ofprotein-protein complexes are explored in four different types of proteinprotein complexes-homodimeric proteins, heterodimeric proteins, enzymeinhibitor complexes, and antibody-protein complexes. The comparison between the complexes highlights differences that reflect their biological roles. numbers (e.g., 60, 180, and 240) of subunits development of algorithms to dock two (see ref. 5). proteins together (6-8), and the structural Previous work has centered on two ascharacterization of protein-protein interpects of protein-protein recognition: the faces. Janin et al. (9), Miller (10), Argos
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